This web page was produced as an assignment for Genetics 564, an undergraduate course at UW-Madison
Homology
What is gene homology?
When two or more species share a gene, which was derived from a common ancestor, these genes are considered homologous. By studying these genes, we have the potential to better understand topics such as species divergence and evolutionary conservation [1]. Additionally, when highly conserved homologs are identified in model organisms, such as mice or fruit flies, they can be used to further study, understand, and potentially treat a variety of human diseases. |
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Conservation of NBN Gene Sequences
Several organisms were found to possess genes homologous to NBN. The percent identity, or amount of similarity between the homologous gene and the human NBN gene, is given for each homolog.
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Discussion
NBN was found to possess a variety of mammalian homologs and one non-mammalian homolog. The gene was highly conserved among mammals, especially primates, with percent identities of 78% and higher. With the exception of chickens, gene homologs were not identified in any non-mammals or invertebrates; however, protein homologs do exist in many of these organisms.
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References:
[1] Homologous genes. (n.d.). Retrieved March 20, 2015, from http://evolution.berkeley.edu/evolibrary/article/1_0_0/eyes_10 |